Top 10 Antidepressants Without a Prescription

Depression has become a frequent companion of modern people. Sometimes it seems that you will not be able to find a way out on your own. But there is a solution, and these are antidepressant drugs, many of which are sold in pharmacies without a prescription. We have compiled a list of the best of them.
 
  Name
  Rating
  Nomination
1 Stressovit 4.52
The most convenient reception
2 Calm Formula Tryptophan 4.41
Serotonin + melatonin for stress and depression
3 Selank 4.34
Unique release form
4 Biorhythm Antistress 4.21
Complex of two tablets
5 Glycine 4.19
Best price
6 Persen 4.07
The best ratio of price and quality
7 Novo-Passit 3.97
Best Cast
8 Afobazole 3.93
The most popular
9 Tenoten 3.75
Complex action
10 Melaxen 3.64
Comfortable sleep to protect against stress

Drug treatment of depression is carried out under the strict supervision of a physician. Most often, complex drugs are used for these purposes, which can only be bought with a prescription. Recently, however, an increasing number of antidepressants have begun to appear in pharmacies, available for free purchase. These medicines have a slight effect, but in many situations they can do their job perfectly, relieve anxiety and irritability, improve mood and general well-being.

Antidepressants sold without a prescription are not able to fight severe manifestations of depression that require more serious therapy. But the need for taking strong drugs is not always there.In most cases, people mistake stress and fatigue for depression, which are effectively corrected by safe and affordable drugs that do not cause addiction and dependence, and also have a minimal number of side effects. If there is no improvement while taking them, then this is a reason to see a doctor.

There are contraindications! Consult your doctor!

Top 10. Melaxen

Rating (2022): 3.64
Accounted for 458 reviews from resources: Yandex.Market, Otzovik, Vrachi.rf, Otabletkah, Protabletky
Comfortable sleep to protect against stress

Melaxen is a drug based on melatonin, which is necessary for proper sleep and rest at night, which increases the body's resistance to stress and depression.

  • Average price: 580 rubles. (24 tab.)
  • Manufacturer: Unipharm (USA)
  • Active ingredient: melatonin

The initial forms of depression are often accompanied by sleep disturbances and disruptions in the body's biological rhythms. To correct the condition at this stage of the disorder, the drug Melaxen will help, which can also, albeit conditionally, be included in the list of over-the-counter antidepressants. A melatonin-based remedy will normalize sleep and wake cycles, make it easier to fall asleep, and also relieve lethargy, fatigue and a feeling of weakness after waking up. Melaksen also has a slight immunostimulating and antioxidant effect. The product does not have the effect of dependence and addiction. The drug has a number of contraindications, it can cause a decrease in concentration and lethargy.

Pros and cons
  • Improved sleep quality and state after waking up
  • Does not cause addiction and addiction
  • Has antioxidant and immunostimulatory effects
  • High price
  • There are contraindications
  • Decreases reaction speed and concentration

Top 9. Tenoten

Rating (2022): 3.75
Accounted for 674 feedback from resources: Yandex.Market, Otzovik, Vrachi.rf, Otabletkah, Protabletky
Complex action

Tenoten not only has a pronounced anti-anxiety effect and helps protect the body from stress and depression, but also improves cerebral circulation, increases concentration and memory.

  • Average price: 330 rubles. (40 tab.)
  • Manufacturer: Materia Medica (Russia)
  • Active ingredient: antibodies to the brain-specific protein S-100 affinity purified

Tenoten lozenges are available in adult and pediatric versions and are indicated to reduce anxiety and increase the body's resistance to stress. The agent also has antihypoxic, nootropic and neuroprotective effects. It also has a mild antidepressant effect. The drug is taken 1-2 tablets per day in courses of 1-3 months. Many doctors believe that the effectiveness of Tenoten is based on the placebo effect, but it does not have real effectiveness. People who took the drug also speak ambiguously about it, but positive reviews are still found.

Pros and cons
  • Nootropic, neuroprotective and antihypoxic action
  • Moderate antidepressant effect
  • An integrated approach to reducing anxiety and stress
  • Not all doctors recognize the effectiveness of the drug

Top 8. Afobazole

Rating (2022): 3.93
Accounted for 1675 reviews from resources: Yandex.Market, Otzovik, Vrachi.rf, Otabletkah, Protabletky
The most popular

Afobazole is the most popular over-the-counter antidepressant in pharmacies and our rating, as evidenced by the large number of reviews about this drug.

  • Average price: 340 rubles. (60 tab.)
  • Manufacturer: Pharmstandard-Leksredstva (Russia)
  • Active ingredient: fabomotizol

Afobazole is a drug with anxiolytic properties, the action of which is aimed at reducing anxiety and relieving irritation. It also helps to fight cognitive and autonomic disorders, showing excellent results in improving memory and concentration, getting rid of somatic manifestations of anxiety. The medicine is indicated for course admission. The first improvements during treatment with Afobazole are noticeable only on the 5th-7th day of use, and the maximum effect is noted on average after 4 weeks, remaining for 10-14 days after the end of the intake. The action of this antidepressant is mild, addiction does not occur during administration. You can find a lot of good reviews about the tool, but some people write that it did not help them.

Pros and cons
  • Average price range
  • Pronounced anti-anxiety effect
  • Popularity and many reviews
  • The effect persists for some time after the end of the reception.
  • The first results are only 5-7 days after the start of treatment
  • Reception 3 times a day
  • There are reviews of the lack of effectiveness

Top 7. Novo-Passit

Rating (2022): 3.97
Accounted for 742 feedback from resources: Yandex.Market, Otzovik, Vrachi.rf, Otabletkah, Protabletky
Best Cast

Novo-Passit contains 7 plant extracts fortified with the anxiolytic guaifenesin. This composition can rightfully be called one of the best for the treatment of chronic stress and mild depression.

  • Average price: 615 rubles. (60 tab.)
  • Manufacturer: TEVA (Czech Republic)
  • Active ingredient: extracts of valerian roots, lemon balm, St. John's wort, hawthorn, passionflower + guaifenesin

Novo-Passit is a product with a combined composition, which presents an optimally selected combination of herbal ingredients and the anxiolytic guaifenesin.The drug has a moderate sedative effect, relieves symptoms of mild anxiety. In the literal sense of the word, this remedy is not an antidepressant, like most other similar drugs sold without a prescription. But to reduce the manifestations of stress, get rid of headaches caused by overstrain, reduce fears, fatigue and absent-mindedness, the remedy will help perfectly. Novo-Passit can be taken by adults and children over 12 years of age. The effect is felt already after the first tablet.

Pros and cons
  • Combined composition based on 7 herbal ingredients
  • Fast soothing and anti-anxiety action
  • Available in tablets and oral solution
  • Suitable for children over 12 years old
  • In some cases, drowsiness and lethargy may occur while taking
  • You cannot drive a car during the course

Top 6. Persen

Rating (2022): 4.07
Accounted for 297 reviews from resources: Yandex.Market, Otzovik, Vrachi.rf, Otabletkah, Protabletky
The best ratio of price and quality

Persen is a popular over-the-counter drug for depression. The medicine is not the most affordable, but it costs less than many analogues and receives mostly positive reviews, optimally combining price and quality.

  • Average price: 410 rubles. (60 tab.)
  • Manufacturer: Lek d.d. (Slovenia)
  • Active ingredient: extracts of valerian, lemon balm, mint

Persen can also be added to the list of over-the-counter drugs for depression. It is a sedative indicated for the treatment of irritability, nervous irritability and insomnia. The completely natural composition is absolutely safe, non-addictive, and after the end of the intake, there is no withdrawal syndrome.In the literal sense, Persen is not an antidepressant, but its use is possible with mild stages of the disorder, stress and overstrain, and helps to significantly reduce the risk of developing severe forms of depression. You can take the remedy both in courses of no more than 1.5 months, and in single doses.

Pros and cons
  • 100% natural composition
  • Non-addictive, no withdrawal effect
  • Suitable for children over 12 years old
  • Costs more than analogues
  • May reduce concentration and psychomotor reactions

Top 5. Glycine

Rating (2022): 4.19
Accounted for 1264 feedback from resources: Yandex.Market, Otzovik, Vrachi.rf, Otabletkah, Protabletky
Best price

Glycine is the lowest priced OTC antidepressant on the list and a Best Value winner.

  • Average price: 32 rubles. (50 tab.)
  • Producer: Biotiki (Russia)
  • Active ingredient: glycine

Glycine is another drug that is not actually an antidepressant, but it helps to solve the problem of irritability, excessive anxiety, poor sleep and other neurosis-like conditions. The active substance of the same name in the composition also helps to increase efficiency, reduce the manifestations of vegetative-vascular disorders. The tool is allowed for both adults and children, it is characterized by maximum safety, it is quite inexpensive. With stress and prerequisites for depression, Glycine is often prescribed as part of complex therapy. There are a lot of reviews about this tool, but the opinions in them sound contradictory. Many who take it notice positive changes in mood and well-being, others do not see the effect.

Pros and cons
  • Affordable cost
  • Safety, no contraindications
  • Can children
  • Lots of reviews
  • There are opinions, including doctors, about the inefficiency

Top 4. Biorhythm Antistress

Rating (2022): 4.21
Accounted for 37 reviews from resources: Reviewer, IRecommend, Eapteka
Complex of two tablets

Biorhythm Antistress are tablets with different composition for taking in the morning and evening and providing high-quality protection against stress during the day and good sleep at night.

  • Average price: 200 rubles. (32 tab.)
  • Producer: Evalar (Russia)
  • Active ingredient: extracts of motherwort, lemon balm, St. John's wort, escholcia, passionflower, vitamins B6, B1, calcium pantothenate

Biorhythm Antistress is a dietary supplement from the popular brand Evalar. The complex offers two types of tablets, which are to be taken in the morning and in the evening. They differ in composition and principle of action. The morning pill will protect against stress throughout the day, helping to fight nervous tension, and the evening pill will help you fall asleep faster and have a great rest in your sleep. The drug is indicated for course use for at least 20 days. The natural composition based on extracts and vitamins is sufficiently safe, but the product is not recommended for children under 18 years of age and pregnant women. The cost of the drug is relatively small, but one package for the course recommended by the manufacturer is not enough.

Pros and cons
  • A complex of two tablets with different composition for taking in the morning and in the evening
  • Natural composition based on extracts and vitamins
  • Average price range
  • One package is not enough for a full course
  • Not allowed for children under 18

Top 3. Selank

Rating (2022): 4.34
Accounted for 140 reviews from resources: Yandex.Market, Otzovik, Otabletkah, Protabletky
Unique release form

Selank is an anti-anxiety drug with antidepressant properties, produced in the form of nasal drops, while all other drugs with a similar effect are presented in tablets.

  • Average price: 570 rubles. (3 ml)
  • Producer: Peptogen (Russia)
  • Active ingredient: threonyl-lysyl-prolyl-arginyl-prolyl-glycine-proline diacetate

Selank is in many ways a unique drug, produced in the format of nasal drops. It has a pronounced anti-anxiety effect, which allows it to be included in the list of antidepressants. In addition, the tool normalizes the level of serotonin, improves cognitive function, memory and learning ability. Selank is used in courses, instilling 2-3 drops into each nostril 3 times a day for 10-14 days. Improvements occur already on the first day of treatment, while drowsiness and lethargy are not observed, which makes it possible to use the remedy by driving a car. The drug does not give addiction, as well as the effect of withdrawal. You can use not only courses, but also one-time.

Pros and cons
  • Does not give a sedative effect, allowed for drivers
  • Relieves anxiety after the first application
  • Can be taken both in courses and one-time
  • High price
  • It is not always convenient to instill drops in the nose three times a day

Top 2. Calm Formula Tryptophan

Rating (2022): 4.41
Accounted for 210 reviews from resources: Yandex.Market, Otzovik, Eapteka
Serotonin + melatonin for stress and depression

Tranquility Formula Tryptophan contains components that promote the production of serotonin, the hormone of happiness during the day, and melatonin, the hormone of comfortable sleep at night.

  • Average price: 805 rubles. (60 tab.)
  • Producer: Evalar (Russia)
  • Active ingredient: L-tryptophan, vitamins B5, B6

Calmness and stress prevention during the day, as well as a comfortable night's sleep can provide dietary supplements Calm formula Tryptophan from Evalar. L-Tryptophan and B vitamins in the composition of the drug contribute to the synthesis of serotonin, which is called the hormone of happiness, and in the dark - melatonin, which is necessary for proper rest at night. It is recommended to take the Tryptophan Calmness Formula twice a day for a month. It is very convenient that one package of dietary supplement is enough for the full course. The tool receives only good reviews. Most people who have tried it note improvements and confirm its effectiveness in the fight against mild forms of depression.

Pros and cons
  • Promotes the production of serotonin during the day and melatonin at night
  • Improves mood, normalizes sleep
  • Good feedback
  • High price

Top 1. Stressovit

Rating (2022): 4.52
Accounted for 54 feedback from resources: Yandex.Market, Otzovik
The most convenient reception

Stress is enough to take just 1 tablet a day, which is very convenient, because most analogues require two or three doses.

  • Average price: 360 rubles. (30 cap.)
  • Producer: Unipharm (Poland)
  • Active ingredient: magnesium oxide, extracts of hop, linden, motherwort, vitamin B6

Stressovit is positioned as a dietary supplement, but it is quite capable of performing the functions of a mild antidepressant. The combination of plant extracts with magnesium and vitamin B6 has a beneficial effect on the nervous system, increases mental and physical performance, and stimulates stress resistance. It is enough to take 1 tablet only once a day for 2-3 weeks, after a month the course can be repeated.The tool is quite safe, but children and pregnant women should not take it. Stressovit is relatively inexpensive, although it cannot be called cheap. Reviews of dietary supplements are good, but there are not many of them yet.

Pros and cons
  • Contains magnesium, soothing plant extracts and vitamin B6
  • Convenient 1 tablet daily
  • The course is only 2-3 weeks
  • Few reviews
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